Dexpramipexole Phase 2 Results Show Efficacy in ALS

Dexpramipexole Phase 2 Results Show Efficacy in ALS

Clinical trial data for the experimental drug show slowing of symptom progression and increase in survival time in people with ALS

ALS TDI Summit: ‘An Incredibly Hopeful Time’

ALS TDI Summit: ‘An Incredibly Hopeful Time’

ALS TDI’s 2011 Leadership Summit included the latest on ALS research and a discussion of speeding the pace of drug development

ALS Clinical Trials Briefs: Cytokinetics, Neuralstem Advance

ALS Clinical Trials Briefs: Cytokinetics, Neuralstem Advance

CK-2017357 is being tested in combination with riluzole; Neuralstem will test delivery of its stem cells into the cervical region of the spinal cord

‘Aberrant Astrocytes’ Kill Motor Neurons in Rats

‘Aberrant Astrocytes’ Kill Motor Neurons in Rats

A subtype of astrocytes — cells that normally protect motor neurons — causes 'unprecedented toxicity' to motor neurons in a rat model of familial ALS

More Evidence for Astrocyte Involvement in ALS

More Evidence for Astrocyte Involvement in ALS

Astrocytes carrying mutated SOD1 genes transplanted into the spinal cords of healthy rats caused deterioration and death of nearby motor neurons

Cover Story
John Shearer and his wife Brenda learned in November 2010 that he has ALS. The couple, who lives in Woodstock, Ga., were told the disease would cause gradual weakening of John’s voluntary muscles, suc...
Featured Articles
In recognition of National Family Caregivers Month, MDA is shining a light on family caregivers across the nation, via a special interactive caregivers’ website, MDA Salutes Caregivers. The site,...
C9ORF72 mutation is most common cause of familial ALS, FTD Two independent research teams have identified a mutation in the gene for chromosome 9 open reading frame 72 (C9ORF72) as the most common...
Editor's note: This is part of a larger story about the science and effects of frontotemporal dementia (FTD) in ALS. For more information, see When the Thinking Parts of the Brain Go Awry in ALS....

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